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GENOSYS Korean glass skin facial

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GENOSYS BIO-MESO™ PDRN Spicule Treatment

Experience the Next Generation of Skin Regeneration

Discover one of Korea’s latest innovations in advanced skin rejuvenation. The GENOSYS BIO-MESO™ PDRN Spicule Treatment combines cutting-edge biotechnology with powerful regenerative ingredients to improve skin health from within—without the use of traditional microneedling devices.

This revolutionary treatment stimulates your skin’s natural renewal process, helping to restore a smoother, brighter, firmer and healthier complexion with minimal downtime.

About GENOSYS

GENOSYS is a globally recognised professional Korean dermocosmetic brand, trusted by skin professionals in more than 50 countries. Developed in Seoul, South Korea, the brand combines advanced biotechnology, clinical research and high-performance skincare to create innovative treatments that deliver visible, long-lasting results.

GENOSYS focuses on supporting the skin’s natural healing abilities through scientifically developed formulations that prioritise skin health, regeneration and barrier repair. Every treatment is designed with both efficacy and safety in mind, making GENOSYS a trusted choice in professional aesthetic clinics worldwide.

What is BIO-MESO™ PDRN?

BIO-MESO™ PDRN is an advanced needle-free bio-microneedling treatment, often referred to as liquid microneedling.

Instead of using a microneedling device, the treatment uses thousands of microscopic natural bio-spicules derived from freshwater sponge. These tiny spicules create temporary micro-channels within the upper layers of the skin, encouraging the skin’s natural repair response whilst allowing active ingredients to penetrate more effectively.

Each spicule is coated with PDRN (Polydeoxyribonucleotide) using GENOSYS’ advanced coating technology, allowing regenerative ingredients to be delivered exactly where the skin needs them most. The result is enhanced skin renewal, increased collagen stimulation and healthier-looking skin—all with significantly less downtime than traditional microneedling.

Why Choose BIO-MESO™ PDRN?

This treatment is ideal for anyone looking to improve overall skin quality without invasive procedures.

The unique combination of bio-spicules and PDRN works by:

  • Stimulating collagen and elastin production
  • Accelerating natural skin renewal
  • Supporting tissue repair and regeneration
  • Improving absorption of active ingredients
  • Strengthening the skin barrier
  • Reducing inflammation
  • Enhancing skin hydration
  • Promoting a brighter, smoother complexion

Unlike many aggressive resurfacing treatments, BIO-MESO™ focuses on improving the overall health of the skin, helping it function at its best whilst achieving naturally radiant results.

Benefits of BIO-MESO™ PDRN

Clients may notice improvements in:

  • Fine lines and wrinkles
  • Loss of firmness and elasticity
  • Dull or tired-looking skin
  • Uneven skin texture
  • Enlarged pores
  • Acne scarring
  • Pigmentation and post-inflammatory marks
  • Dehydrated skin
  • Rough skin texture
  • Skin barrier damage
  • Overall skin radiance

With a course of treatments, skin appears healthier, smoother, firmer and more luminous as collagen production continues over time.

Key Active Ingredients

PDRN (Polydeoxyribonucleotide)

PDRN is a powerful regenerative ingredient derived from purified salmon DNA. It is widely recognised within aesthetic medicine for supporting skin repair, stimulating fibroblast activity and encouraging collagen and elastin production. It also helps calm inflammation whilst promoting healthier, stronger skin. Bio-Spicules

Natural microscopic spicules create temporary micro-channels that stimulate the skin’s natural healing response and significantly improve the delivery of active ingredients without traditional needles. Peptide Complex

Advanced peptides help support collagen production, improve skin firmness and soften the appearance of fine lines whilst strengthening the skin structure. Panthenol (Vitamin B5)

Known for its soothing and hydrating properties, Panthenol helps reduce irritation, strengthens the skin barrier and promotes faster skin recovery.

Ceramides

Ceramides replenish essential skin lipids, helping to lock in moisture and protect against environmental damage while improving overall skin resilience.

Who Is This Treatment Suitable For?

BIO-MESO™ PDRN is suitable for most skin types and is particularly beneficial for clients experiencing:

  • Early signs of ageing
  • Mature skin
  • Acne-prone skin
  • Acne scarring
  • Uneven skin tone
  • Pigmentation concerns
  • Dehydrated skin
  • Sensitive skin requiring barrier support
  • Dull, tired or stressed skin
  • Loss of elasticity

Your skin will always be assessed during your consultation to ensure this treatment is the most suitable option for your individual concerns.

What Can You Expect?

During your treatment, the bio-spicules are gently massaged into the skin. You may experience a mild prickling or tingling sensation during and shortly after the procedure, which is completely normal.

Following treatment, your skin may appear slightly pink for a few hours, and you may experience light dryness or flaking over the following few days as the skin naturally renews itself.

Results continue to improve over the following weeks as collagen production increases and skin regeneration takes place.

Aftercare

To achieve the best possible outcome, we recommend:

Keeping your skin well hydrated

Wearing SPF 30–50 daily

Avoiding exfoliating acids, retinoids and active ingredients for several days

Avoiding excessive heat, swimming pools and saunas for 48 hours

Following your personalised aftercare advice provided during your appointment

Treatment Course

For the best results, we generally recommend:

  • A course of 3–6 treatments
  • Treatments every 3–4 weeks
  • Maintenance treatments every 2–3 months depending on your skin goals

Your treatment plan will always be tailored to your skin condition and desired results.

Why Clients Love BIO-MESO™

✓ Needle-free alternative to traditional microneedling

✓ Minimal downtime

✓ Supports natural collagen production

✓ Improves skin health from within

✓ Suitable for a wide range of skin concerns

✓ Brighter, smoother and firmer skin

✓ Professional Korean skincare technology backed by scientific research

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